Taking Wannian County of Jiangxi Province as the research area, constructing the evaluation index system of rural residential multi-functions, using the methods of full arrangement polygon comprehensive graphic method, Spearman correlation analysis, spatial autocorrelation analysis and explicit comparative advantage weight index, this paper analyzes the spatial characteristics of rural residential multi-functions and carries out comprehensive functional zoning. The results show that 1) Wannian County presents the characteristics of “living function and production function are the main, followed by ecological function”, which is spatially heterogeneous. 2) There is a complex interaction between the multi-functions of rural residential areas, especially the synergistic relationship between living function and production function. 3) Based on the method of “zoning + revision”, Wannian County is divided into I, II, III, IV and V regions under the different goal orientations of coordinated development, function leading and green revitalization. Considering the interaction between functions based on the leading functions of rural residential areas, the delimitation of comprehensive functional areas is an effective way to optimize rural areas, which is of great significance to rural sustainable development.