青蒿素及其衍生物的电化学性质研究 Ⅱ氯化血红素存在下的青蒿素还原机理

北京大学学报（自然科学版）

青蒿素及其衍生物的电化学性质研究 Ⅱ
氯化血红素存在下的青蒿素还原机理

陈扬¹, 朱世民²,陈洪渊²

¹东南大学分子与生物分子电子学教育部重点实验室，南京，210096; ²南京大学化学系，南京，210093

收稿日期:2000-07-13 出版日期:2001-03-20 发布日期:2001-03-20

Study on the Electrochemical Behaviors of Artemisinin(Qinghaosu) and Its Derivatives Ⅱ
Reduction Mechanism of Artemisinin in the Presence of Hemin

CHEN Yang¹, ZHU Shimin²，CHEN Hongyuan²

¹National Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing, 210093; ²Department of Chemistry, Nanjing University, Nanjing, 210096

Received:2000-07-13 Online:2001-03-20 Published:2001-03-20

摘要/Abstract

摘要： 用电化学方法研究了青蒿素与氯化血红素之间的相互作用。青蒿素在玻璃碳电极上于-1.08V处能发生一个2电子转移的不可逆还原。即使在低至4.0×10^-8mol/L氯化血红素存在下，青蒿素仍可被催化还原，阴极过电位降低了600mV。配合物EDTA-Fe(Ⅲ)具有类似氯化血红素的催化性质，它降低了QHS阴极过电位590mV。在这个体系中，青蒿素在碳电极上的还原是一个借助于氯化血红素催化的还原过程，氯化血红素的存在降低了青蒿素还原活化能，促进了青蒿素的分解。文中讨论了该反应的还原机理。

关键词: 青蒿素, 氯化血红素, 催化还原, 循环伏安, EDTA-Fe(Ⅲ)

Abstract: The interaction between artemisinin and hemin was investigated by electrochemical methods. Artemisinin was irreversibly reduced at -1.08V via a two-electron transfer at the glassy carbon electrode. In the presence of concentration of hemin as low as 4.0×10^-8mol/L, artemisinin can be reduced via the hemin-catalysis and its original cathodic peak at -1.08V completely disappeared. The cathodic overpotential of artemisinin is decreased ca.600mV. This process is verified by the fact that complex EDTA-Fe(Ⅲ) can also promote the artemisinin reduction with decreasing the cathodic overpotential of artemisinin for 590mV. These results show that the reduction of artemisinin at the glassy carbon electrode is a catalytic process with the aids of hemin. Hemin can greatly decrease the cathodic activation energy of the reduction of artemisinin and promote the decomposition of artemisinin.

Key words: Artemisinin, Hemin, catalytic reduction, cyclic voltammetry, EDTA-Fe(Ⅲ)

中图分类号:

O657.1

陈扬, 朱世民,陈洪渊. 青蒿素及其衍生物的电化学性质研究 Ⅱ
氯化血红素存在下的青蒿素还原机理[J]. 北京大学学报（自然科学版）.

CHEN Yang,ZHU Shimin,CHEN Hongyuan. Study on the Electrochemical Behaviors of Artemisinin(Qinghaosu) and Its Derivatives Ⅱ
Reduction Mechanism of Artemisinin in the Presence of Hemin[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

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https://xbna.pku.edu.cn/CN/Y2001/V37/I2/255

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