北京大学学报(自然科学版)

青蒿素及其衍生物的电化学性质研究 Ⅱ
氯化血红素存在下的青蒿素还原机理

陈扬1, 朱世民2,陈洪渊2   

  1. 1东南大学分子与生物分子电子学教育部重点实验室,南京,210096; 2南京大学化学系,南京,210093
  • 收稿日期:2000-07-13 出版日期:2001-03-20 发布日期:2001-03-20

Study on the Electrochemical Behaviors of Artemisinin(Qinghaosu) and Its Derivatives Ⅱ
Reduction Mechanism of Artemisinin in the Presence of Hemin

CHEN Yang1, ZHU Shimin2,CHEN Hongyuan2   

  1. 1National Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing, 210093; 2Department of Chemistry, Nanjing University, Nanjing, 210096
  • Received:2000-07-13 Online:2001-03-20 Published:2001-03-20

摘要: 用电化学方法研究了青蒿素与氯化血红素之间的相互作用。青蒿素在玻璃碳电极上于-1.08V处能发生一个2电子转移的不可逆还原。即使在低至4.0×10-8mol/L氯化血红素存在下,青蒿素仍可被催化还原,阴极过电位降低了600mV。配合物EDTA-Fe(Ⅲ)具有类似氯化血红素的催化性质,它降低了QHS阴极过电位590mV。在这个体系中,青蒿素在碳电极上的还原是一个借助于氯化血红素催化的还原过程,氯化血红素的存在降低了青蒿素还原活化能,促进了青蒿素的分解。文中讨论了该反应的还原机理。

关键词: 青蒿素, 氯化血红素, 催化还原, 循环伏安, EDTA-Fe(Ⅲ)

Abstract: The interaction between artemisinin and hemin was investigated by electrochemical methods. Artemisinin was irreversibly reduced at -1.08V via a two-electron transfer at the glassy carbon electrode. In the presence of concentration of hemin as low as 4.0×10-8mol/L, artemisinin can be reduced via the hemin-catalysis and its original cathodic peak at -1.08V completely disappeared. The cathodic overpotential of artemisinin is decreased ca.600mV. This process is verified by the fact that complex EDTA-Fe(Ⅲ) can also promote the artemisinin reduction with decreasing the cathodic overpotential of artemisinin for 590mV. These results show that the reduction of artemisinin at the glassy carbon electrode is a catalytic process with the aids of hemin. Hemin can greatly decrease the cathodic activation energy of the reduction of artemisinin and promote the decomposition of artemisinin.

Key words: Artemisinin, Hemin, catalytic reduction, cyclic voltammetry, EDTA-Fe(Ⅲ)

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