关键词: 动脉瘤, 线圈栓塞, 血液动力学, 计算流体动力学, 数值模拟

Abstract: Blood flow characteristics which are affected by the locations of coil for partially blocked aneurysm for a lateral aneurysm with a straight parent vessel is numerically simulated in order to find the coil locations effective for aneurysm embolization. Supposing blood incompressible，viscous，Newtonian flow, non-elasticity of the wall, three-dimensional N-S equations are solved using artificial compressibility algorithm at pulsatile conditions. The maximum /minimum Reynolds number is set at about 475/152 based on diameter of parent vessel. The Womersley number is set to 2.5. These values are representative of the middle cerebral arteries in vivo data. The velocity, pressure field, mean wall shear stress on the aneurysm and inflow rate are calculated. The results show that velocity, pressure in aneurysm sac, mean shear stress on the aneurysm and inflow rate reduce greatly in the blocked model as compared to the non-blocked model. Inflow rate and mean wall shear stress in the neck blocked models are much lower than that in the dome blocked model and the lowest in the proximal neck blocked model. Since lower wall shear stress and smaller inflow provide hemodynamic environment promoting blood cloting, proximal or distal neck should be the effective coil location for a giant aneurysm embolization.

Key words: coil embolization, lateral intracranial aneurysm, hemodynamics, computational fluid dynamics, numerical simulation