胃癌及胃炎的临床诊断中红外光谱方法研究

胃癌及胃炎的临床诊断中红外光谱方法研究

徐怡庄¹,徐智²,凌晓锋²,赵莹³,刘学新³,潘庆华⁴,王冰冰¹,张啸⁵,任予⁶,杨丽敏¹,杨文君⁴,来国桥⁴,张元福¹,翁诗甫¹,周孝思²,徐端夫³,吴瑾光^1,7

¹北京大学化学与分子工程学院，稀土材料化学及应用国家重点实验室，北京，100871；²北京大学第三医院普通外科,北京，100083；³中国科学院化学研究所，北京，100080；⁴杭州师范学院及其附属医院，杭州，310015；⁵杭州市第一人民医院，杭州，310006；⁶西安交通大学第一医院普通外科，西安，710061；⁷通讯作者，E-mail:wujg@pku.edu.cn

收稿日期:2006-07-24 出版日期:2007-07-20 发布日期:2007-07-20

Clinical Study on Gastric Carcinoma and Gastritis Using mid FT IR Spectroscopy

XU Yizhuang¹,XU Zhi²,LING Xiaofeng²,ZHAO Ying³,LIU Xuexin³,PAN Qinghua⁴,WANG Bingbing¹,ZHANG Xiao⁵,REN Yu⁶,YANG Limin¹,YANG Wenjun⁴,LAI Guoqiao⁴,ZHANG Yuanfu¹,WENG Shifu¹,ZHOU Xiaosi²,XU Duanfu³,WU Jinguang^{1, 7}

¹The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871; ²Department of Surgery, Third hospital, Peking University, Beijing， 100083; ³Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080; ⁴Hangzhou Normal University and Affiliated Hospital, HangZhou, 310015; ⁵Hangzhou First People's Hospital，HangZhou，310006; ⁶Department of Oncology Surgery, the First Hospital of Xi?an Jiaotong University, Xi?an, 710061；⁷Corresponding author, E-mail: wujg@pku.edu.cn

Received:2006-07-24 Online:2007-07-20 Published:2007-07-20

摘要/Abstract

摘要： 用中红外光谱ATR方法对110例冻存，89例新鲜离体胃组织样品，80例新鲜胃镜样品进行研究，同时用中红外光纤法进行了6例在体原位的检测。对110例冻存样品，各项指标与病理检测结果的符合率平均可达到90%以上。新鲜离体与在体原位也大致同病理结果符合。为了研究地区差别，对杭州市第一医院消化科80例胃镜样品进行了光谱测定，根据病变程度可以看到相应的光谱变化。结果表明中红外光谱法用于各种胃炎等胃部疾病和恶性肿瘤的检测是一种有效方便的方法。

关键词: 胃镜, 中红外方法, 胃炎

Abstract: 110 gastric disease samples stored in liquid nitrogen, 89 fresh gastric disease samples after operation and 80 fresh tissues obtained from gastroscope were investigated using mid FTIR ATR method. At the same time, the spectra of gastric tumor of six patients were measured in vivo in the process of operation using mid IR fiber optics technique. The detected indexes from IR were compared with the pathological biopsy and the results show that various indexes are in agreement with the results of pathological diagnosis more than 90%. The same consequences were observed for fresh tissues and samples in vivo detection. To investigate the difference of the incidence of this disease in south and north of China, 80 fresh tissues from gastroscope, including various types of gastric diseases, for example, superficial gastritis, chronic gastritis, moderate atrophic gastritis and severe atrophic gastritis, and so on, obtained from Hangzhou First People?s Hospital were measured. The spectroscopic measurements show that different stages of pathologic changes of stomach have corresponding spectroscopic characteristics. The results demonstrate that mid IR ATR method is an effective way for detection of various gastritis diseases and carcinoma of stomach.

Key words: gastric tissues from gastroscope, mid IR ATR method, gastritis

中图分类号:

O 653

徐怡庄,徐智,凌晓锋,赵莹,刘学新,潘庆华,王冰冰,张啸,任予,杨丽敏,杨文君,来国桥,张元福,翁诗甫,周孝思,徐端夫,吴瑾光. 胃癌及胃炎的临床诊断中红外光谱方法研究[J]. 北京大学学报（自然科学版）.

XU Yizhuang,XU Zhi,LING Xiaofeng,ZHAO Ying,LIU Xuexin,PAN Qinghua,WANG Bingbing,ZHANG Xiao,REN Yu,YANG Limin,YANG Wenjun,LAI Guoqiao,ZHANG Yuanfu,WENG Shifu,ZHOU Xiaosi,XU Duanfu,WU Jinguang. Clinical Study on Gastric Carcinoma and Gastritis Using mid FT IR Spectroscopy[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

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https://xbna.pku.edu.cn/CN/Y2007/V43/I4/441