关键词: 维持性血液透析, 心理干预, 渐进性肌肉放松训练, 脑波同步化, 脑-肠轴, 治疗依从性, 生活质量

Abstract: To study whether psychological intervention can improve maintained hemodialysis(MHD) patients' mental state, increase their compliance to treatment, and mend their physiological function and quality of life, seventy-seven MHD patients were randomly assigned to the intervention group (39 patients) or the control group (38 patients). The control group received the conventional therapy which included hemodialysis 3 times/week and recombinant human erythropoietin (rHuEPO) at dosages of 100unites/(kg·week^-1) to 150unites/(kg·week^-1) by i.v and subcutaneous injection. The intervention group received the conventional therapy combined with psychological intervention, which included brainwave synchronizer and progressive relaxation. Thirty-six patients of the intervention group and 34 patients of the control group completed the study. Psychological variables and hematic parameter in both groups were assessed three days before and after the intervention. The patients who received psychological intervention therapy showed better mental state, higher global quality of life and higher values of HB, RBC, HCT and serum calcium, lower values of serum phosphor, kalium, BUN and IWGR% than those in the control group. There is no significant difference in serum Scr between both groups.

Key words: maintained hemodialysis(MHD), psychological intervention, progressive muscle relaxation, brainwave synchronizer, brain-gut axis, Compliance to treatment, quality of life