北京大学学报（自然科学版）

家猪基因组含有大量保守非编码区

钟兰1,2,李松岗1,2, 李蔚3   

  1. 1北京大学生命科学学院，北京，100871；2中国科学院基因组信息学中心暨华大基因研究中心，北京, 101300；3中国科学院生物物理所生物信息研究室，北京，100101
  • 收稿日期:2003-02-17 出版日期:2003-11-20 发布日期:2003-11-20

Numerous of Conserved Non-coding Sequences in the Pig (Sus scrofa) Genome

ZHONG Lan1, 2，LI Songgang1, 2, LI Wei3   

  1. 1College of Life Science, Peking University, Beijing, 100871；2Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, 101300; 3Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101
  • Received:2003-02-17 Online:2003-11-20 Published:2003-11-20

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摘要： 用190万条家猪随机读序分别比对人和小鼠的基因组，除去已知基因的外显子和新预测的人的编码区，得到大量含有保守非编码区的家猪序列。11.05%的家猪读序含有“猪－人”保守的非编码区序列，3.13%的家猪读序含有“猪－鼠”保守的非编码区片段，1.86%的家猪读序包含“猪－人－鼠”三者保守的非编码区区域。三者保守的非编码区序列跟人的相似性明显高于跟小鼠的相似性。另外，很多人、小鼠的非编码RNA基因跟上述含有保守非编码片段的家猪序列至少比对上一次。

关键词: 随机读序, 保守的非编码序列, 非编码RNA基因

Abstract: Aligning 1.9 millions of porcine random reads to the genomes of human and mouse respectively, and then filtering out known exons and newly predicted human coding regions, the authors obtained large amount of reads containing conserved non-coding sequences (CNSs). Among the porcine reads, 11.05% contained pig-human two-way CNSs, 3.13% contained pig-mouse two-way CNSs and 1.86% contained pig-human-mouse three-way CNSs, and the three-way CNSs are more similar with human than with mouse. Besides, many of the human and mouse ncRNA genes had similarity with these above porcine reads containing CNSs at least once.

Key words: random reads, conserved non-coding sequence(CNS), non-coding RNA(ncRNA)

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