酯键溶血磷脂酸和醚键溶血磷脂酸的全合成

北京大学学报（自然科学版）

酯键溶血磷脂酸和醚键溶血磷脂酸的全合成

陈家华, 张延东

生物有机与分子工程教育部重点实验室，北京大学化学与分子工程学院，北京，100871

收稿日期:2002-03-01 出版日期:2003-03-20 发布日期:2003-03-20

Total Synthesis of Acyl- and Alkyl- LPA

CHEN Jiahua, ZHANG Yandong

Ministry of Education Key Lab of Bioorganic Chemistry & Molecular Engineering, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Received:2002-03-01 Online:2003-03-20 Published:2003-03-20

摘要/Abstract

摘要： 报导了酯键溶血磷脂酸和醚键溶血磷脂酸消旋体的合成。通过相同的中间体2-O-苄基甘油，它们分别经过6步反应被制得。这种方法可以用来制备溶血磷脂酸的半抗原，从而用于制备抗体。

关键词: 溶血磷脂酸, 化学合成, 消旋体

Abstract: Lysophosphatidic acid (LPA), including 1-acyl LPA and 1-O-alkyl LPA, were synthesized chemically as racemates. Through the same intermediate, 2-O-benzyl glycerol, they were respectively synthesized by six steps. The synthetic approach provided a facile method for the synthesis of LPA hapten that could be used to prepare LPA antigen for producing LPA antibodies.

Key words: Lysophosphatidic acid, chemical synthesis, racemates

中图分类号:

陈家华, 张延东. 酯键溶血磷脂酸和醚键溶血磷脂酸的全合成[J]. 北京大学学报（自然科学版）.

CHEN Jiahua,ZHANG Yandong. Total Synthesis of Acyl- and Alkyl- LPA[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

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https://xbna.pku.edu.cn/CN/Y2003/V39/I2/151