光活性酮咯酸衍生物的合成与拆分

北京大学学报（自然科学版）

光活性酮咯酸衍生物的合成与拆分

杨鳌,张雅薇,李坤宇,关烨第

北京大学化学与分子工程学院，北京，100871

收稿日期:2001-05-11 出版日期:2002-03-20 发布日期:2002-03-20

The Synthesis and Resolution of the Optical Active Derivatives of Ketorolac

YANG Ao，ZHANG Yawei，LI Kunyu，GUAN Yedi

College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Received:2001-05-11 Online:2002-03-20 Published:2002-03-20

摘要/Abstract

摘要： 以11个氨基酸酯以及L和D-α苯乙胺作为手性辅基，与外消旋酮咯酸生成一对光学活性的酰胺衍生物，再用简单易行的柱层析方法分离其非对映异构体。实验表明，分离效果与手性辅基上R¹和R²基团的相对大小有密切关系。

关键词: 酮咯酸, 非对映异构体

Abstract: Authors have used elevenL-amino acid eaters and L-, D-α-methylbenzyl amine as chiral auxiliaries to react with racimic ketorolac. Then authors got optical amides. The diastereoisomeric mixture were separated by column-chroatography on silica gel. The results of separation depend on the structure of R¹ and R² on the chiral auxiliaries.

Key words: ketorolac, diastereoisomers

中图分类号:

O626

杨鳌,张雅薇,李坤宇,关烨第. 光活性酮咯酸衍生物的合成与拆分[J]. 北京大学学报（自然科学版）.

YANG Ao,ZHANG Yawei,LI Kunyu,GUAN Yedi. The Synthesis and Resolution of the Optical Active Derivatives of Ketorolac[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.