用分子复制法制备具有分子识别功能的高分子膜

北京大学学报（自然科学版）

用分子复制法制备具有分子识别功能的高分子膜

王红英¹,吕秋丰¹,曹少魁¹,孙宏²

¹郑州大学材料工程系，郑州，450052；²郑州大学化学化工学院，郑州，450052

收稿日期:2000-07-13 出版日期:2001-03-20 发布日期:2001-03-20

Theophylline Recognition Copolymer Membranes Prepared by Molecular Imprinting Method

WANG Hongying¹，Lü Qiufeng¹，CAO Shaokui¹, SUN Hong²

¹Department of Materials Engineering, Zhengzhou University, Zhengzhou, 450052; ²College of Chemistry and Chemical Engineering, Zhengzhou University, Zhengzhou, 450052

Received:2000-07-13 Online:2001-03-20 Published:2001-03-20

摘要/Abstract

摘要： 将分子复制法应用于功能性高分子膜的制备中，以1，3-二甲基黄嘌呤(茶碱，THO)为模板分子，含有成膜骨干残基和功能残基的丙烯腈-丙烯酸的共聚物为膜材料，用相转化沉淀法制备了具有THO分子识别功能的高分子膜。FT-IR及NMR测试结果表明：制备的高分子膜中，THO模板分子和膜中的丙烯酸功能残基存在着氢键键合作用。大量的极性醋酸水溶液可抽出膜中的模板分子。THO溶液和与模板分子具有相似结构的1，3，7-三甲基黄嘌呤(咖啡因，CAF)溶液的基质透过实验结果：进入膜结构中THO分子的量远大于CAF分子，这表明制备的高分子膜具有THO分子识别功能。实验结果还表明：进入膜结构中THO分子的量与相转化沉淀法制膜时刮膜液中模板分子的添加量成正比。

关键词: 相转化沉淀法制膜, 分子复制, 模板分子, 功能性高分子膜

Abstract: Using molecular imprinting method, the 1, 3-dimethylxanthine(Theophylline, THO)molecular recognition membranes, containing AN segments as membrane formation sites and AA segments as functional sites, were prepared by the phase inversion technique. Here, THO was selected as a template molecule. The hydrogen bonding between AA segments and the THO templates was measured by FT-IR and NMR. The THO templates can be removed from the membrane through washing with acetic acid aqueous solution. The permeation of THO through the membranes is far more than that of 1, 3, 7-trimethylxanthine(Caffeine, CAF), which demonstrated the function of THO molecular recognition of the membrane. The results also show that the increase of the THO templates concentration in the cast solution caused an increase of THO amounts taken into the copolymer membrane.

Key words: phase inversion technique, molecular imprint, template molecule, functional copolymer membrane

中图分类号:

TQ028.8

王红英,吕秋丰,曹少魁,孙宏. 用分子复制法制备具有分子识别功能的高分子膜[J]. 北京大学学报（自然科学版）.

WANG Hongying,Lü Qiufeng,CAO Shaokui,SUN Hong. Theophylline Recognition Copolymer Membranes Prepared by Molecular Imprinting Method[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

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