关键词: 傅立叶变换红外光谱, 白血病, 骨髓红细胞

Abstract: Eight samples of erythrocytes in bone marrow coming from patients affected by acute myeloid leukemia (AML) and nine samples from patients suffered from chronic myeloid leukemia (CML) were studied by FTIR spectroscopy. Spectroscopic differences of leukemic erythrocytes were observed between AML and CML samples. The ratios of the integrated areas of the band at 1540cm^-1 due to the protein components of erythrocytes, and of the band from 1084cm^-1 mainly involving the vibration of the O-P-O linkages and C-O groups in ribosome, are closer and lower in AML samples than the corresponding ratios in CML samples. The amide Ⅰ band in AML is broader than that in CML. These differences indicate the different contributions of red cells in erythrocytic series in the erythropoietic development from proerythroblast to matured erythrocytes, and the results imply the maturation of red cells in bone marrow are related to the proliferation of leukemic cells. The noticeable differences may have important implications for analyzing and evaluating leukemia.

Key words: Fourier transform infrared spectroscopy, leukemia, erythrocyte