关键词: 中子俘获治疗, 脂质体, 钆配合物, 癌细胞

Abstract: Liposome is an effective nuclide delivery agent for neutron capture therapy. In this paper liposomes containing encapsulated gadolinium complex (LGd) were prepared and characterized. The influence of formulation factors such as pH, ionic strength, buffer, and storage time upon the stability of liposomes was investigated. The uptake rate constant and its concentration dependence of LGd in tumor cells were compared in vitro with that of Gd complex itself. The results indicate that the uptake rate of LGd in tumor cells increases to eight times as much as that of Gd-EDTA, but the release rate of Gd from tumor cells containing LGd is remarkably lower than that from the tumor cells containing Gd-EDTA. The results reveal that LGd would be a potential drug for neutron capture therapy of cancer.

Key words: neutron capture therapy, liposome, gadolinium complex, tumor cell