关键词: Chandler环, 血栓, 趋轴效应, 聚集

Abstract: In the artificial thrombus machines such as Chandler loop, the thrombus is always formed at the frontal meniscus. This Phenomenon is amazing and puzzling for many years. Although people have known well about the fluid field in artificial thrombus machines, the reason why thrombus always forms at the specific position is still not clear. To study the mechanism of this phenomenon, we established a new model in which we consider the blood as the mixture of plasma and blood cells. The plasma is Newtonion and the cells are simulated by particles. For the existance of the tube wall, the particle will not always move with the liquid particle, but a little slower than the fluid, and more importantly, the fluid and the tube wall will produce a lift force which causes the particle to keep away from the walls. We assumes that the density of particles is low so that we can neglect the effects of the particles while calculating the fluid field. From the dynamic equations of the particle involving the lift force, we computed the motion of the particles. The results show that no matter where the particle sets off, it will tend to a stationary position near the fronter meniscus, this indicates that the lift force is oneof the main reason to cause the gathering of blood cells at the fronter meniscus of the artificial thrombus machine. Since the gathering of blood cells is a necessary event to form the thrombus, the lift force is very important to the thrombus formation in the machine, and it might be the working theory of the machines. This model are also applied for studying the effects of several factors, including the Reynolds number, the viscosity of liquid, and the size of the particles, on the gathering of blood cells and thrombus formation.

Key words: Chandler loop, thrombus, lift force, gathering