This review systematically summarizes the development of purely organic thermally activated delayed fluorescence (TADF) materials and provides a comprehensive elucidation of their luminescence mechanisms and fundamental characteristics. As one of the most promising next-generation electroluminescent materials, TADF compounds demonstrate significant potential in biomedical applications owing to their minimal singlet-triplet energy gap, outstanding photophysical properties, structural tunability, and excellent biocompatibility. Emphasis is placed on recent advances in the application of these materials in fluorescence imaging, time-resolved imaging, biosensing, and photodynamic therapy.

系统地介绍纯有机热活化延迟荧光(TADF)材料的发展历程, 深入地阐释其发光机理与基本特性。作为新一代最具潜力的电致发光材料, TADF材料凭借其极小的单三重态能量差、优异的光物理性能、结构可调性和良好的生物相容性, 在生物医学领域展现出广阔的应用前景。重点探讨该类材料在荧光成像、时间分辨成像、生物传感以及光动力治疗等方向的应用研究进展。