Abstract: In order to find replacer for Metronidazole and drug selection. Some diesters or esters of acids containing nitrogen with Metronidazole were designed and synthesized, which have difference in water-solubility. Metronidazole was reacted with the corresponding amino or imino multi-carboxylic acid compounds in the presence of acetic anhydride or thionyl chloride or DCC. The intermediate of nitrilotriacetic acid with Ac₂O was identified by Mass Spectrum. Out of three diesters two are novel.

Key words: Metronidazole, amino carboxylic acid, amino acid, diester

摘要： 为寻找羟乙基甲硝唑的替代物，分别采用酸酐法、酰氯法或DCC法，将氨基羧酸与羟乙基甲硝唑反应，得到5个亲水性不同的单酯或二酯，用MS谱确证了次氨基三乙酸与乙酸酐反应的中间物，并对得到的酯的¹H-NMR谱进行了初步研究。3个二酯中，有2个未见文献报道。

关键词: 羟乙基甲硝唑, α-氨基羧酸, 氨基酸, 二酯