Abstract: Authors have used elevenL-amino acid eaters and L-, D-α-methylbenzyl amine as chiral auxiliaries to react with racimic ketorolac. Then authors got optical amides. The diastereoisomeric mixture were separated by column-chroatography on silica gel. The results of separation depend on the structure of R¹ and R² on the chiral auxiliaries.

Key words: ketorolac, diastereoisomers

摘要： 以11个氨基酸酯以及L和D-α苯乙胺作为手性辅基，与外消旋酮咯酸生成一对光学活性的酰胺衍生物，再用简单易行的柱层析方法分离其非对映异构体。实验表明，分离效果与手性辅基上R¹和R²基团的相对大小有密切关系。

关键词: 酮咯酸, 非对映异构体