Dynamics Model of Type 2 Diabetes with Inflammation in Islets and Treatment Strategies

doi:10.13209/j.0479-8023.2020.038

Acta Scientiarum Naturalium Universitatis Pekinensis ›› 2021, Vol. 57 ›› Issue (2): 199-208.DOI: 10.13209/j.0479-8023.2020.038

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Dynamics Model of Type 2 Diabetes with Inflammation in Islets and Treatment Strategies

LIN Zhili¹, LEI Lei², LI Changrun³, LI Fangting^1,†

1. School of Physics, Center for Quantitative Biology, Peking University, Beijing 100871
2. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101
3. The Fourth School of Clinical Medicine, Peking University, Beijing 100871

Received:2020-02-06 Revised:2020-04-11 Online:2021-03-20 Published:2021-03-20
Contact: LI Fangting, E-mail: lft(at)pku.edu.cn

胰岛炎症导致的2型糖尿病发病过程的动力学模型及治疗策略

林智立¹, 雷蕾², 李长润³, 李方廷^1,†

1. 北京大学物理学院, 北京大学定量生物学中心, 北京 100871 2. 中国科学院生物物理研究所, 生物大分子国家重点实验室, 中国科学院科教融合生物大分子卓越创新中心, 北京 100101 3. 北京大学第四临床医学院, 北京 100871

通讯作者: 李方廷, E-mail: lft(at)pku.edu.cn
基金资助:
科技部重大科学研究计划(MSTC2015CB910300)资助

Abstract

Abstract:

In order to reveal the pathogenesis of type 2 diabetes caused by inflammation in islets, this paper established the mathematical model of interaction between β cell and macrophage, including the process of IL-1β production and macrophage infiltration in islets. The combined effects of glucose and free fatty acid on IL-1β was analyzed to reveal the dynamic mechanism of islet inflammation in the progression of type 2 diabetes. By analyzing this model’s sensitivity to parameters variation, the feasible optimal treatment strategies was given to different type 2 diabetes patients.

Key words: type 2 diabetes, islets inflammation, dynamic model, macrophage infiltration, IL-1β

摘要：

为了揭示胰岛炎症导致2型糖尿病发生发展的机制, 建立胰岛β细胞和巨噬细胞相互作用的数学模型, 包括IL-1β的产生和巨噬细胞的浸润过程, 研究高浓度葡萄糖和游离脂肪酸对IL-1β的共同作用, 揭示胰岛炎症在2型糖尿病进程中的动力学机理。通过对模型中动力学参数的敏感性分析, 提出针对不同患病情况的可能的优化治疗策略。

关键词: 2型糖尿病, 胰岛炎症, 动力学模型, 巨噬细胞浸润, IL-1β

LIN Zhili, LEI Lei, LI Changrun, LI Fangting. Dynamics Model of Type 2 Diabetes with Inflammation in Islets and Treatment Strategies[J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2021, 57(2): 199-208.

林智立, 雷蕾, 李长润, 李方廷. 胰岛炎症导致的2型糖尿病发病过程的动力学模型及治疗策略[J]. 北京大学学报自然科学版, 2021, 57(2): 199-208.

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URL: https://xbna.pku.edu.cn/EN/10.13209/j.0479-8023.2020.038

https://xbna.pku.edu.cn/EN/Y2021/V57/I2/199

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Dynamics Model of Type 2 Diabetes with Inflammation in Islets and Treatment Strategies

胰岛炎症导致的2型糖尿病发病过程的动力学模型及治疗策略

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