Based on information entropy, deviation coefficient of structural change rates and vector auto-regression model, taking Quzhou County as a typical case, this paper made a comprehensive study on the dynamic change characteristics and interactive relationship of industrial structure and land use structure of rural areas in Huang-Huai-Hai Plain. The results show that in recent years, the evolution of industrial structure in Quzhou County has experienced the process of primary industry dominating, balance of primary and secondary industries and secondary industry dominating. The great proportion of land for the primary industry leads to the extremely unbalanced land use structure, but the land use structure is developing to an equilibrium state. Industrial structure adjustment and land use structure adjustment are uncoordinated, and land use structure adjustment lags behind, but there is a long-term and stable relationship between them. Before 2009, the adjustment of industrial structure promoted the change of land use structure, but after that, the causality was opposite. In the later stage, the driving effect of land use structure adjustment on the subsequent optimization of land use structure and the upgrading of industrial structure was more lasting and significant. Over a period time in the future, optimizing the land use structure of the three industries by improving the land use efficiency of the primary industry, exploiting the land use potential of the secondary industry, and widening the land use scope of the tertiary industry is an effective way to promote the continuous upgrading of industrial structure in rural areas of Huang-Huai-Hai Plain.