Reduction of Amino Acids Containing Hydroxy Side Chain to β-Amino Alcohol and Preparation of Their Peptide Alcohol

Acta Scientiarum Naturalium Universitatis Pekinensis

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Reduction of Amino Acids Containing Hydroxy Side Chain to β-Amino Alcohol and Preparation of Their Peptide Alcohol

SUN Binyuan, TIAN Guiling, WANG Wei, JIN Ning, YE Yunhua

College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Received:1998-03-10 Online:1999-07-20 Published:1999-07-20

含侧链羟基氨基酸还原为β-氨基醇及其肽醇的制备

孙滨源,田桂玲,王伟,金宁,叶蕴华

北京大学化学与分子工程学院，北京，100871

Abstract

Abstract: A convenient reduction of threonine and serine without protection of their hydroxy group to threoninol and serinol was reported. Preparation of peptide alcohol containing c-threoninol and serinol by using a new organophosphorus compound DEPBT as coupling reagent was also studied and discussed.

Key words: Threonine, serine, peptide alcohols, reduction, peptide coupling reagent

摘要： 用一种未见文献报道的简便方法，将侧链羟基不保护的苏氨酸，丝氨酸还原制备了苏氨醇，丝氨醇。并用新型的有机磷缩合试剂DEPBT成功地合成了C-端为苏氨醇，丝氨醇的二肽醇和四肽醇。

关键词: 苏氨酸, 丝氨酸, 肽醇, 多肽缩合试剂, DEPBT

CLC Number:

O622.3

SUN Binyuan,TIAN Guiling,WANG Wei,JIN Ning,YE Yunhua. Reduction of Amino Acids Containing Hydroxy Side Chain to β-Amino Alcohol and Preparation of Their Peptide Alcohol[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

孙滨源,田桂玲,王伟,金宁,叶蕴华. 含侧链羟基氨基酸还原为β-氨基醇及其肽醇的制备[J]. 北京大学学报（自然科学版）.

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Reduction of Amino Acids Containing Hydroxy Side Chain to β-Amino Alcohol and Preparation of Their Peptide Alcohol

含侧链羟基氨基酸还原为β-氨基醇及其肽醇的制备

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