Acta Scientiarum Naturalium Universitatis Pekinensis
WANG Ying1, CHEN Laitong2
A modified method for the estimation of gene copy number in genome is proposed. It based upon the size ratio between the cloned gene and its haploid genome. From the size fraction and the amount of genomic DNA used for analysis, the gene copy number could be estimated from the data of dot blot or Southern blot analysis. Using the procedure proposed by this study, the copy numbers of human α1-antitrypsin gene and rat RALRS-1 repetitive sequence were determined.
gene copy number,
human α1-antitrypsin gene,
rat RALRS-1 repetitive sequence
WANG Ying,CHEN Laitong. A Modified Procedure for the Determination of the Gene Copy Number[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.
王瑛,陈来同 . 基因拷贝数分析的研究[J]. 北京大学学报（自然科学版）.
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