Abstract: Lysophosphatidic acid (LPA), including 1-acyl LPA and 1-O-alkyl LPA, were synthesized chemically as racemates. Through the same intermediate, 2-O-benzyl glycerol, they were respectively synthesized by six steps. The synthetic approach provided a facile method for the synthesis of LPA hapten that could be used to prepare LPA antigen for producing LPA antibodies.

Key words: Lysophosphatidic acid, chemical synthesis, racemates

摘要： 报导了酯键溶血磷脂酸和醚键溶血磷脂酸消旋体的合成。通过相同的中间体2-O-苄基甘油，它们分别经过6步反应被制得。这种方法可以用来制备溶血磷脂酸的半抗原，从而用于制备抗体。

关键词: 溶血磷脂酸, 化学合成, 消旋体