Abstract: An enantioselective borane reduction of prochiral ketones directly catalyzed by (S)-(indolin-2-yl)methanol or (S)-indoline-2-carboxylic acid was examined and the resultant chiral secondary alcohols with 82%～87% enantiomeric excess were obtained.

Key words: asymmetric borane reduction, (S)-(indolin-2-yl)methanol, (S)-ind oline-2-carboxylic acid, ketones

摘要： 直接应用非修饰的简单氨基醇和氨基酸((S)-吲哚醇或(S)-吲哚酸)在硼烷体系中催化前手性酮进行不对称还原。通过反应条件的优化，大大增强了手性催化剂的催化能力，产物手性二级醇的e.e.值可以达到82%～82%，与文献报道的结果相比有了很大的提高。

关键词: 不对称硼烷还原, (S)-吲哚醇, (S)-吲哚酸, 酮