Synthesis of Chiral Glycerol Derivatives

Acta Scientiarum Naturalium Universitatis Pekinensis

Synthesis of Chiral Glycerol Derivatives

GUO Yong'en, WANG Nengdong, CHEN Jiahua, ZOU Feng, CHEN Liumin, JIN Sheng, FU Bin, ZHANG Xiu, ZHANG Yandong, YOU Zejin, LIU Dongmei

Ministry of Education Key Lab of Bioorganic Chemistry & Molecular Engineering, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, 100871

Received:2002-01-12 Online:2002-11-20 Published:2002-11-20

手性丙三醇衍生物的合成

郭永恩,王能东,陈家华,邹锋,金声,付滨,陈柳民,张秀,张延东,游泽金,刘东梅

生物有机与分子工程国家教育部重点实验室，化学生物学系，化学与分子工程学院，北京大学，北京，100871

Abstract

Abstract: One new chiral derivative of propanetriol, (R)-2-benzyloxy-3-(2-tetrahyd ropyranyloxy) propanol was designed and synthesized; and (R)-2-benzyloxy-3 -(4-methoxybenzyloxy) propanol was prepared with a new method using natural tartaric acid as starting material. They are chiral synthons for lysophosphatidic acid, platelet-activating factors, lipoteichoic acid, and other compounds containing asymmetric propanetriol backbone.

Key words: chiral synthons, glycerol, synthesis

摘要： 以天然酒石酸为原料，设计并合成了一个未见文献报道的手性丙三醇衍生物即R-2-苯甲氧基-3-(2-四氢吡喃氧基)丙醇，及用新方法制备了R-2-苯甲氧基-3-(4-甲氧基苯甲氧基)丙醇。它们是合成溶血磷脂酸(LPA)，血小板活性因子(PAF)，脂肪胞壁酸以及其他具有手性丙三醇骨架化合物的手性源。

关键词: 手性源, 丙三醇, 合成

CLC Number:

O622.3

GUO Yong'en,WANG Nengdong,CHEN Jiahua,ZOU Feng,CHEN Liumin,JIN Sheng,FU Bin,ZHANG Xiu,ZHANG Yandong,YOU Zejin,LIU Dongmei. Synthesis of Chiral Glycerol Derivatives[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

郭永恩,王能东,陈家华,邹锋,金声,付滨,陈柳民,张秀,张延东,游泽金,刘东梅. 手性丙三醇衍生物的合成[J]. 北京大学学报（自然科学版）.

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URL: https://xbna.pku.edu.cn/EN/

https://xbna.pku.edu.cn/EN/Y2002/V38/I6/744

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