Abstract: By means of the micronucleus test of whole mice bone marrow and fetus liver blood, we studied the protective effects of three biological preparations (garlic lycium chinense liquid, dextran and fuxikang) on lead acetic induced genetic damage of mouse somatic cells. The results showed that, when the lead acetic in the mice raised to 30mg/kg (1/4LD₅₀), the frequency of micronucleus would raise to a high level, and these three biological preparations obviously demonstrated their protective effect to the animals. After seven and fourteen days drinking of garlic Lycium Chinense liquid and doxtran the suppression rate to the incidences of micronucleus were 68%; 49% and 52%; 48% respectvely. After nineteen days drinking of Fuxikang, the suppression rate was 55%. The garlic Lycium Chinense liquid and dextran alao had protective effect on lead induced genetic demage in pregenant mice and fetus liver. Preliminary research showed that: first, they all had distinctive anti-saltation effect; second, the effect of garlic lycium chinense liquid had better effect than that of dextan;third, the three biological preparations had no mutagentic activity.

Key words: garlic, lycium chinense, dextran, fuxikang, micronucleus test, lead acetic

关键词: 大蒜, 枸杞, 右旋糖酐, 富硒康, 微核试验, 醋酸铅