Abstract: Four analogs of effective antigenic peptide P141 of 28kDa glutathione S-transferase of schistosoma mansoni have been designed according to similarity of the amino acid residues in the structure, Chou-Fasman's secondary structural parameters P_α, P_β and P_t values and hydrophilicity of amino acid residues, respectively. They were synthesized by using solid phase method and their antigenicities were assayed by ELISA method with anti-schistosomal polyclonal antibodies to surface membrane antigen. The structure-activity relationship of P141 and its analogs was discussed.

Key words: Schistosoma mansoni, Glutathione S-transferase, Antigenic peptide, structureactivity relationship

摘要： 以曼氏血吸虫28kDa谷胱甘肽S-转移酶的有效抗原肽P141为先导肽，通过分别改变在结构上、Chou-Fasman构象参数上和亲水性上相似的氨基酸残基设计并合成了4个类似物，通过ELISA法测定了它们对血吸虫表膜抗原多克隆抗体的抗原性，通过类似物与P141的活性比较讨论了构效关系。

关键词: 曼氏血吸虫, 谷胱甘肽S-转移酶, 抗原肽, 构效关系