Abstract: Reactions of ^99mTcO₄^-,acetylphenylhydrazine (PhNHNHCOCH₃), reducing agent (Sn²⁺, Triphenylphosphine, Tris(m-sulfophenyl) phosphine) and ligand Et₂NCS₂Na in CH₃OH, C₂H₅OH and H₂O solvent systems were studied. The final new product [^99mTc^VCl(NPh)(Et₂NCS₂)₂] was characterized by paper chromatography, thin layer chromatography and paper electrophoresis, and also partition coefficients in cyclohexane/water and n-octanol/water systems were measured. The biodistribution of this complex was also determined, showing that the complex does not accumulate in heart, nor brain.

Key words: [^99mTc=N-Ph]³⁺ core complex, radiopharmaceuticals

摘要： 研究了在CH₃OH，C₂H₅OH，H₂O 3种溶剂体系中^99mTcO₄^-，乙酰苯肼(PhNHNHCOCH₃, APH)、还原剂(Sn²⁺、三苯基膦、三(间磺酸钠)苯基膦)与配体Et₂NCS₂Na的反应，以制备含［^99mTc^V=N—Ph］³⁺核的新配合物［TcVCl(NPh)(Et₂NCS₂)₂］。用放射性纸层析、薄层色谱及放射性纸电泳对反应产物进行了检测，并测定了不同条件下产物在环己烷/水、正辛醇/水中的分配系数，得到了制备含［^99mTc^V=N—Ph］³⁺核的配合物的相关条件，还进一步研究了这种配合物的动物分布。结果是该配合物在正常小白鼠体内不稳定，心和脑的摄取率低。

关键词: ［^99mTc^V=N—Ph］³⁺核配合物, 放射性药物