Study of Interaction of Water-Soluble Fullerene Derivatives with DNA

Abstract

Abstract: The interaction of ds DNA with a water-soluble C₆₀ derivative was studied using surface electrochemistry of DNA modified electrode and UV-Vis spectroscopy. It was found that the absorbed band of C₆₀ shifted positively in company with the hypochromic effect. Co(phen)₃²⁺ was used as indicator to study the interaction. The results show that this kind of C₆₀ derivative can interact strongly with ds DNA, the bind site is the major groove of helix.

Key words: fullerene, surface electrochemical methods, DNA, interaction

摘要： 发展了一种新的研究方法，即DNA修饰金电极表面电化学方法，结合紫外光谱研究了一种水溶性C₆₀衍生物——C₆₀乙醇胺加成物与ds DNA的相互作用。结果表明，富勒烯衍生物是以DNA双螺旋的大沟为作用靶点的。

关键词: 富勒烯, 表面修饰电化学方法, DNA, 相互作用

CLC Number:

FANG Pengfei,ZHAO Yuandi,PANG Daiwen,CHEN Yuanyin. Study of Interaction of Water-Soluble Fullerene Derivatives with DNA[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

方鹏飞,赵元弟,庞代文,陈远荫. DNA与水溶性C₆₀衍生物的相互作用[J]. 北京大学学报（自然科学版）.

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