Abstract: The α-alkylation products of γ-butyrolactone can be gained via two simple and convenient steps:(E)-α-Alkenyl-γ-butyrolactone compounds were synthesized from condensation of corresponding aromatic aldehydes and γ-butyrolactone, using common base such as MeONa and EtONa. Then the (E)-α-Alkenyl-γ-butyrolactones were reduced to α-alkyl-γ-butyrolactones by using sodium hypophosphite with Pd/C catalyst, which is named to be reaction of catalytic transfer hydrogenation.

Key words: α-alkylation of γ-butyrolactone, condensation, Pd/C-sodium hypophosphite, catalytic transfer

摘要： 采用两步简单反应，顺利地得到α-取代的γ-丁内酯。首先，在醇钠存在下，严格控制反应温度为0～10℃，以内酯与芳香醛类化合物，选择性地缩合为α-烯基内酯产率40%～99%，进而采用催化转移氢化的方法，在Pd/C存在下，用NaH₂PO₂氢化还原上述缩合中间物，使有效地转化为α-烷基化γ-丁内酯，产率55%～99%。总体上，该方法能有效地得到目标化合物，具有方法简单易行，操作方便，反应条件温和，试剂价廉和产率相对较高的特点。

关键词: γ-丁内酯α-烷基化, 缩合, Pd/C-次亚磷酸钠, 催化转移氢化