Isolation and Identification of 2-(1′, 2′, 3′, 4′-Tetrahydroxybutyl)-6-(2″, 3″, 4″-Trihydroxybutyl)-Pyrazine from Panax pseudoginseng var notoginseng

Acta Scientiarum Naturalium Universitatis Pekinensis

Isolation and Identification of 2-(1′, 2′, 3′, 4′-Tetrahydroxybutyl)-6-(2″, 3″, 4″-Trihydroxybutyl)-Pyrazine from Panax pseudoginseng var notoginseng

LI Qi，YAN Aixin，YE Yunhua，XING Qiyi

Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Received:2000-03-07 Online:2001-03-20 Published:2001-03-20

三七中2-(1′, 2′, 3′, 4′-四羟基丁基)-6-(2, 3, 4-三羟基丁基)吡嗪的分离、纯化和结构鉴定

李琦,阎爱新,叶蕴华,邢其毅

生物有机与分子工程国家教育部重点实验室，北京大学化学与分子工程学院，北京，100871

Abstract

Abstract: A water soluble polyhydroxy derivative of 1, 4-diazine has been isolated from Panax pseudoginseng var notoginseng for the first time. Its structure was determined as 2-(1′, 2′, 3′, 4′-tetrahydroxybutyl)-6-(2″, 3″, 4″-trihydroxybuty)-pyrazine by MS, NMR, 1H-1H COSY, 1H-13C COSY, HMBC etc., it was also confirmed by chemical synthesis.

Key words: panax notoginseng, polyhydroxy pyrazine derivative, water-soluble constituent

摘要： 从三七水溶性成分中首次分离得到一个多羟基吡嗪衍生物。该化合物经MS，NMR，¹H-¹HCOSY，¹³C-¹HCOSY，HMBC等鉴定其结构为2-(1′, 2′, 3′, 4′-四羟基丁基)-6-(2, 3, 4-三羟基丁基)吡嗪。将分离样品与化学合成的化合物进行了对照，进一步证明了该化合物的结构。

关键词: 三七, 多羟基吡嗪化合物, 水溶性组分

CLC Number:

O626.415

LI Qi,YAN Aixin,YE Yunhua,XING Qiyi. Isolation and Identification of 2-(1′, 2′, 3′, 4′-Tetrahydroxybutyl)-6-(2″, 3″, 4″-Trihydroxybutyl)-Pyrazine from Panax pseudoginseng var notoginseng[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

李琦,阎爱新,叶蕴华,邢其毅. 三七中2-(1′, 2′, 3′, 4′-四羟基丁基)-6-(2, 3, 4-三羟基丁基)吡嗪的分离、纯化和结构鉴定[J]. 北京大学学报（自然科学版）.

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https://xbna.pku.edu.cn/EN/Y2001/V37/I2/286