Abstract: The enriched stable isotope tracer technique combined with Neutron Activation Analysis (NAA) and differential centrifugation was utilized to investigate the subcellular distribution of rare earth elements Sm and Yb in rat liver. ¹⁵²Sm and ¹⁶⁸Yb were selected for experiment as representatives of the light and heavy REEs, respectively. In order to verify the analytical quality, some standard reference materials were used. The distribution in subcellular fractions was similar for Sm and Yb, the highest contents of Sm and Yb were found in mitochondria, while the lowest in nuclei.

Key words: rare earth element (REE), neutron activation analysis (NAA), enriched stable isotope tracer, subcellular fraction

摘要： 采用可活化富集稳定同位素¹⁵²Sm和¹⁶⁸Yb作为示踪剂，结合差速离心分离和中子活化分析技术(NAA)初步研究了稀土元素Sm和Yb在大鼠肝脏亚细胞组分中的分布。分析结果表明，Sm和Yb在亚细胞组分中的浓度分布为：溶酶体>微粒体>线粒体>细胞核>胞液。线粒体中Sm和Yb所占比例最高，而细胞核中最低。

关键词: 稀土元素, 中子活化分析, 富集稳定同位素, 亚细胞组分