Acta Scientiarum Naturalium Universitatis Pekinensis

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Clinical Study on Gastric Carcinoma and Gastritis Using mid FT IR Spectroscopy

XU Yizhuang1,XU Zhi2,LING Xiaofeng2,ZHAO Ying3,LIU Xuexin3,PAN Qinghua4,WANG Bingbing1,ZHANG Xiao5,REN Yu6,YANG Limin1,YANG Wenjun4,LAI Guoqiao4,ZHANG Yuanfu1,WENG Shifu1,ZHOU Xiaosi2,XU Duanfu3,WU Jinguang1, 7   

  1. 1The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871; 2Department of Surgery, Third hospital, Peking University, Beijing, 100083; 3Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080; 4Hangzhou Normal University and Affiliated Hospital, HangZhou, 310015; 5Hangzhou First People's Hospital,HangZhou,310006; 6Department of Oncology Surgery, the First Hospital of Xi?an Jiaotong University, Xi?an, 710061;7Corresponding author, E-mail: wujg@pku.edu.cn
  • Received:2006-07-24 Online:2007-07-20 Published:2007-07-20

胃癌及胃炎的临床诊断中红外光谱方法研究

徐怡庄1,徐智2,凌晓锋2,赵莹3,刘学新3,潘庆华4,王冰冰1,张啸5,任予6,杨丽敏1,杨文君4,来国桥4,张元福1,翁诗甫1,周孝思2,徐端夫3,吴瑾光1,7   

  1. 1北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京,100871;2北京大学第三医院普通外科,北京,100083;3中国科学院化学研究所,北京,100080;4杭州师范学院及其附属医院,杭州,310015;5杭州市第一人民医院,杭州,310006;6西安交通大学第一医院普通外科,西安,710061;7通讯作者,E-mail:wujg@pku.edu.cn

Abstract: 110 gastric disease samples stored in liquid nitrogen, 89 fresh gastric disease samples after operation and 80 fresh tissues obtained from gastroscope were investigated using mid FTIR ATR method. At the same time, the spectra of gastric tumor of six patients were measured in vivo in the process of operation using mid IR fiber optics technique. The detected indexes from IR were compared with the pathological biopsy and the results show that various indexes are in agreement with the results of pathological diagnosis more than 90%. The same consequences were observed for fresh tissues and samples in vivo detection. To investigate the difference of the incidence of this disease in south and north of China, 80 fresh tissues from gastroscope, including various types of gastric diseases, for example, superficial gastritis, chronic gastritis, moderate atrophic gastritis and severe atrophic gastritis, and so on, obtained from Hangzhou First People?s Hospital were measured. The spectroscopic measurements show that different stages of pathologic changes of stomach have corresponding spectroscopic characteristics. The results demonstrate that mid IR ATR method is an effective way for detection of various gastritis diseases and carcinoma of stomach.

Key words: gastric tissues from gastroscope, mid IR ATR method, gastritis

摘要: 用中红外光谱ATR方法对110例冻存,89例新鲜离体胃组织样品,80例新鲜胃镜样品进行研究,同时用中红外光纤法进行了6例在体原位的检测。对110例冻存样品,各项指标与病理检测结果的符合率平均可达到90%以上。新鲜离体与在体原位也大致同病理结果符合。为了研究地区差别,对杭州市第一医院消化科80例胃镜样品进行了光谱测定,根据病变程度可以看到相应的光谱变化。结果表明中红外光谱法用于各种胃炎等胃部疾病和恶性肿瘤的检测是一种有效方便的方法。

关键词: 胃镜, 中红外方法, 胃炎

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