Studies on the Function of Metallothionein to Scavenge Hydroxyl Radical

Acta Scientiarum Naturalium Universitatis Pekinensis

Studies on the Function of Metallothionein to Scavenge Hydroxyl Radical

ZHENG Junheng, LI Haiyang, RU Gang, RU Binggen

College of Life Sciences, Peking University, Beijing, 100871

Received:1997-12-30 Online:1999-07-20 Published:1999-07-20

金属硫蛋白清除羟自由基功能的研究

郑军恒,李海洋,茹刚,茹炳根

北京大学生命科学学院，北京，100871

Abstract

Abstract: A simple method of determining hydroxyl radical scavenging effects of metallothionein (MT) was developed. The hydroxyl radical scavenging effects of various oxidative degrees MT and isoforms were investigated. The results indicate that the hydroxyl radical scavenging effects of variously oxidative MT positively correlate with their sulfhydryl group content; with the same sulfhydryl group content, the hydroxyl radical scavenging effects of ZnMT-1 is stronger than that of ZnMT-2; and the capacity of ZnMTs is far stronger than that of GSH and Cystein.

Key words: metallothionein, hydroxyl radical, isoform

关键词: 金属硫蛋白, 羟自由基, 亚型

CLC Number:

Q516

ZHENG Junheng,LI Haiyang,RU Gang,RU Binggen. Studies on the Function of Metallothionein to Scavenge Hydroxyl Radical[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

郑军恒,李海洋,茹刚,茹炳根. 金属硫蛋白清除羟自由基功能的研究[J]. 北京大学学报（自然科学版）.

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