Abstract: A new concept Tip Chemistry is proposed, and several representative studies we conducted along with tip chemistry are presented, including using a chemically functionalized scanning probe microscopy(SPM) tip to monitor the local dissociation of surface acid-base groups, directly estimating chemical bonding strength by adhesion force measurements, and fabricating nanostructures by localizing chemical reactions with SPM tips. In these studies, a chemically-designed SPM tip plays a key role, which serves as the probe, the site, and the lens of chemical reactions, respectively.

Key words: Tip chemistry, force titration, localized reaction, self-assembled monolayers, Tip chemistry, force titration, localized reaction, self-assembled monolayers

摘要： 提出针尖化学的概念和围绕这一新概念开展的代表性研究工作。利用功能化的扫描探针显微镜(SPM)的针尖，考察自组装膜表面酸碱基团的局域解离性质、测定化学键的强度、聚焦化学反应制备纳米结构等。SPM针尖分别起着化学反应的探针、场所和透镜的作用。

关键词: 针尖化学, 力滴定, 聚焦化学反应, 自组装单分子膜, 针尖化学, 力滴定, 聚焦化学反应, 自组装单分子膜