The Synthesis and Separating of S, S-and R, S-5-benzoyl-2, 3-dihydro-1H-Pyrrolizine-1-Carboxyl-Amino Acid Esters

Acta Scientiarum Naturalium Universitatis Pekinensis

Previous Articles Next Articles

The Synthesis and Separating of S, S-and R, S-5-benzoyl-2, 3-dihydro-1H-Pyrrolizine-1-Carboxyl-Amino Acid Esters

LU Yiming, GUO Jian, HUA Wenting

College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871

Received:1997-08-05 Online:1998-11-20 Published:1998-11-20

5-苯甲酰基-2, 3-二氢-1H-吡呤-1-甲酰氨基酸酯的合成及其光活性异构体拆分

卢一民, 郭健, 花文廷

北京大学化学与分子工程学院，北京，100871

Abstract

Abstract: The title compounds 2-7 have been synthesized.This paper provides asimple and convenient separation method of diasteromers from 5-benzdyl-2, 3-dihydro-1H-Pyrrolizine-1-carboxylic acid and amino acid esters.

Key words: pyrrolizine, synthesis, ketorolac

摘要： 合成了7个5-苯甲酰基-2，3-二氢-1H-吡呤-1-甲酸衍生物，并用简便的柱层析法分离了其中S，S-和R，S-型非对映异构体。

关键词: 吡呤环, 合成, 酮咯酸

CLC Number:

O626

LU Yiming,GUO Jian,HUA Wenting. The Synthesis and Separating of S, S-and R, S-5-benzoyl-2, 3-dihydro-1H-Pyrrolizine-1-Carboxyl-Amino Acid Esters[J]. Acta Scientiarum Naturalium Universitatis Pekinensis.

卢一民, 郭健, 花文廷. 5-苯甲酰基-2, 3-二氢-1H-吡呤-1-甲酰氨基酸酯的合成及其光活性异构体拆分[J]. 北京大学学报（自然科学版）.

[1]	ZHU Ting, KANG Huixing, KE Xinran, ZHANG Yan. Dynamics of Photosynthetic Active Radiation and Photosynthetic Characteristics of Rice Leaves at Two Canopy Heights [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2021, 57(4): 723-732.
[2]	ZHU Di,LIU Ranran,LI Hailong,CHEN Tao,TIAN Wenyu,SUN Mao,LI Chun,LIU Chunli. ynthesis of Titania Powder with Different Particle Sizes [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2010, 46(4): 525-530.
[3]	DUAN Xiaofeng,XU Xuegong. Regional Differences Evaluation onthe Comprehensive Benefit of Marine Resources Development and Utilization [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2009, 45(6): 1055-1060.
[4]	WANG Kui,DONG Haiying,CHENG Xu. Clock Skew Scheduling for Area Optimization [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2009, 45(1): 29-34.
[5]	DUAN Xiaofeng,XU Xuegong. Regional Forest Ecosystem Services Assessment: A Case Study of Shandong Province [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2006, 42(6): 751-756.
[6]	WANG Hui,PEI Weiwei,ZHANG Shiwei,SUN Guobin. Synthesis and Crystal Structure of(R)-2-Hydroxymethyl-1-aza-4-thiaspiro［4.5］decane [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2004, 40(6): 849-854.
[7]	CHENG Yong,WU Xihong,CHI Huisheng. A Study on Prosodic Boundaries Location and Synthesized Units Selection Algorithms in Mandarin Speech Synthesis [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2004, 40(3): 451-457.
[8]	CHEN Jiahua,ZHANG Yandong. Total Synthesis of Acyl- and Alkyl- LPA [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2003, 39(2): 151-157.
[9]	GUO Yong'en,WANG Nengdong,CHEN Jiahua,ZOU Feng,CHEN Liumin,JIN Sheng,FU Bin,ZHANG Xiu,ZHANG Yandong,YOU Zejin,LIU Dongmei. Synthesis of Chiral Glycerol Derivatives [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2002, 38(6): 744-749.
[10]	YANG Ao,ZHANG Yawei,LI Kunyu,GUAN Yedi. The Synthesis and Resolution of the Optical Active Derivatives of Ketorolac [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2002, 38(2): 169-174.
[11]	JIANG Nan,WANG Lin,WANG Jianbo. The Reaction Mechanism and Synthetic Application of α-Diazo Carbonyl Compounds [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2001, 37(4): 570-576.
[12]	JIANG Nan,WANG Lin,WANG Jianbo. The Reaction Mechanism and Synthetic Application of α-Diazo Carbonyl Compounds [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2001, 37(4): 570-576.
[13]	CHEN Yantao,HUA Wenting. Formation of the p-Toluenesulphinyl Anion from the Diester of N-Tosyl Alanine with 2, 6-Bis(hydroxylmethyl) pyridine and Its Nucleophilic Addition Product with 2, 6-Bis(chloromethyl) pyridine [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2001, 37(4): 439-443.
[14]	MA Hongtao,WANG Yi,BAO Xinhe. Study on the Surface Location of Reactive Metals of Rh-Mn/SiO₂ Catalyst in Ethanol Synthesis from Syngas [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2001, 37(2): 210-214.
[15]	GAO Wentao,ZHENG Zhuo,CHEN Huilin. Study on Synthesis and Reactions of Acetyl-substituted Troponoids With Aromatic Aldehyde [J]. Acta Scientiarum Naturalium Universitatis Pekinensis, 2001, 37(2): 205-209.

The Synthesis and Separating of S, S-and R, S-5-benzoyl-2, 3-dihydro-1H-Pyrrolizine-1-Carboxyl-Amino Acid Esters

5-苯甲酰基-2, 3-二氢-1H-吡呤-1-甲酰氨基酸酯的合成及其光活性异构体拆分

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics