Acta Scientiarum Naturalium Universitatis Pekinensis

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The Synthesis and Separating of S, S-and R, S-5-benzoyl-2, 3-dihydro-1H-Pyrrolizine-1-Carboxyl-Amino Acid Esters

LU Yiming, GUO Jian, HUA Wenting   

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871
  • Received:1997-08-05 Online:1998-11-20 Published:1998-11-20

5-苯甲酰基-2, 3-二氢-1H-吡呤-1-甲酰氨基酸酯的合成及其光活性异构体拆分

卢一民, 郭健, 花文廷   

  1. 北京大学化学与分子工程学院,北京,100871

Abstract: The title compounds 2-7 have been synthesized.This paper provides asimple and convenient separation method of diasteromers from 5-benzdyl-2, 3-dihydro-1H-Pyrrolizine-1-carboxylic acid and amino acid esters.

Key words: pyrrolizine, synthesis, ketorolac

摘要: 合成了7个5-苯甲酰基-2,3-二氢-1H-吡呤-1-甲酸衍生物,并用简便的柱层析法分离了其中S,S-和R,S-型非对映异构体。

关键词: 吡呤环, 合成, 酮咯酸

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